Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) → HCID 23537382, compound

HRID 1792580Notes

Reaction equation

HRID 1792580 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[N:11]2[CH:12]=[C:13]([C:16]3[C:17]([C:40]4[CH:45]=[CH:44][C:43]([OH:46])=[CH:42][CH:41]=4)=[N:18][N:19]([C:21]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH:20]=3)[CH:14]=[CH:15][C:10]2=[N:9][CH:8]=1.Cl.Cl[CH2:49][CH2:50][N:51]1[CH2:56][CH2:55][O:54][CH2:53][CH2:52]1>>[N:51]1([CH2:50][CH2:49][O:46][C:43]2[CH:42]=[CH:41][C:40]([C:17]3[C:16]([C:13]4[CH:14]=[CH:15][C:10]5[N:11]([C:7]([C:2]6[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=6)=[CH:8][N:9]=5)[CH:12]=4)=[CH:20][N:19]([C:21]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)([C:34]4[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=4)[C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[N:18]=3)=[CH:45][CH:44]=2)[CH2:56][CH2:55][O:54][CH2:53][CH2:52]1

Participants

3

Reactant 2

HCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)HCID 135763129HCID 135763129, compound

Product 1

HCID 23537382HCID 23537382, compoundYield 58.8%

Procedure

90 mg 4-{4-[3-(pyridin-2-yl)imidazo[1,2-a]pyridin-6-yl]-1-trityl-1H-pyrazol-3-yl}phenol (compound in Example 353) and 42 mg N-(2-chloroethyl)morpholine hydrochloride were reacted under the same conditions as in Example 190, to give 63 mg of the title compound as a colorless amorphous matter.

Sources & evidence

ORD record
ord-7b9e373061c54e4fbb41b4aba55e3137
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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