Dimethylamine → HCID 22032295, compound

Participants

Reaction Steps

A mixture of 296 mg {4-[4-(3-pyridin-2-ylimidazo[1,2-a]pyridin-6-yl)-1-trityl-1H-pyrazol-3-yl]phenyl}methanol (compound in Example 359), 844 mg manganese (IV) oxide and 20 mL chloroform was heated for 1 hour under reflux. The reaction solution was cooled to remove insolubles, and the filtrate was evaporated. 264 mg crude product of 4-[4-(3-pyridin-2-ylimidazo[1,2-a]pyridin-6-yl)-1-trityl-1H-pyrazol-3-yl]benzaldehyde was obtained as a pale brown amorphous. From 100 mg of this aldehyde derivative and 35 μL dimethylamine (50% aqueous solution), 81 mg of the title compound was obtained as a colorless amorphous under the same conditions as in Production Example 153.

Provenance & Evidence