HCID 22032168, compound → HCID 22031477, compound

HRID 1792587Notes

Reaction equation

HRID 1792587 reaction equation
[CH3:1][S:2][C:3]1[S:7][C:6]([C:8]2[N:12]3[CH:13]=[C:14]([C:17]4[C:18]([C:41]5[CH:50]=[CH:49][C:44]([C:45](OC)=[O:46])=[CH:43][CH:42]=5)=[N:19][N:20]([C:22]([C:35]5[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=5)([C:29]5[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=5)[C:23]5[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=5)[CH:21]=4)[CH:15]=[CH:16][C:11]3=[N:10][CH:9]=2)=[CH:5][CH:4]=1.CSC1SC(C2N3C=C(C4C(C5C=CC(C(OCC)=O)=CC=5)=NN(C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)C=4)C=CC3=NC=2)=CC=1>>[CH3:1][S:2][C:3]1[S:7][C:6]([C:8]2[N:12]3[CH:13]=[C:14]([C:17]4[C:18]([C:41]5[CH:42]=[CH:43][C:44]([CH2:45][OH:46])=[CH:49][CH:50]=5)=[N:19][N:20]([C:22]([C:23]5[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=5)([C:29]5[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=5)[C:35]5[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=5)[CH:21]=4)[CH:15]=[CH:16][C:11]3=[N:10][CH:9]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 22032168HCID 22032168, compoundHCID 22032328HCID 22032328, compound

Product 1

HCID 22031477HCID 22031477, compound

Procedure

124 mg of the title compound was obtained as a pale yellow solid by the same method as in Example 359 from 196 mg of the mixture of methyl 4-{4-[3-(5-methylsulfanylthiophen-2-yl)-imidazo[1,2-a]pyridin-6-yl]-1-trityl-1H-pyrazol-3-yl}benzoate and ethyl 4-{4-[3-(5-methylsulfanylthiophen-2-yl)imidazo[1,2-a]pyridin-6-yl]-1-trityl-1H-pyrazol-3-yl]benzoate obtained in the synthesis process in Example 375.

Sources & evidence

ORD record
ord-bc57ab5fcfb14623a8ba0cbfcc62fd66
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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