Potassium Phosphate, Tribasic → HCID 22032135, compound

Participants

Reaction Steps

1.6 g methyl 5-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-3-pyrazolyl]-2-thiophene carboxylate (compound in Production Example 117), 0.6 g 2-(6-bromoimidazo[1,2-a]pyridin-3-yl)-1,3-thiazole (compound in Production Example 57), 0.68 g tripotassium phosphate, 0.12 g tetrakis (triphenylphosphine)palladium and 30 mL N,N-dimethylformamide were heated at 85° C. for 2.5 hours under nitrogen atmosphere. After the solvent was removed, the residue was purified by silica gel chromatography (hexane/ethyl acetate) to give 1.2 g of the title compound.

Provenance & Evidence