Dimethylamine → HCID 23537798, compound

Participants

Reaction Steps

100 mg 5-{4-[3-(1,3-thiazol-2-yl)imidazo[1,2-a]pyridin-6-yl]-1-trityl-1H-3-pyrazolyl}-2-thiophene carboxylic acid (compound in Example 443), together with 66 μL triethylamine and 25 μL isobutyl chloroformate, was stirred for 30 minutes in 4 mL tetrahydrofuran under ice-cooling in a stream of nitrogen, and then 0.79 mL dimethylamine was added thereto and stirred at room temperature for 3 hours. Water was added to the reaction solution which was then extracted with ethyl acetate, and the organic layer was dried over anhydrous sodium sulfate and purified by NH silica gel column chromatography (ethyl acetate/hexane) to give 29 mg of the title compound (colorless solid).

Provenance & Evidence