HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 23537349, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Amino-4-methylthiazole | HCID 74143 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | HCID 22032217 | HCID 22032217 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 23537349 | HCID 23537349 | 84.9% |
Reaction Steps
170 mg 2-fluoro-4-[6-(1-trityl-1H-4-pyrazolyl)imidazo-[1,2-a]pyridin-3-yl]benzoic acid (compound in Example 472) and 34.4 mg 2-amino-4-methyl-1,3-thiazole were allowed to react overnight with 146 mg benzotriazol-1-yloxy-tris-(dimethylamino)phosphonium hexafluorophosphate and 50 μL triethylamine in 6 mL dichloromethane. The reaction solution was purified by an NH silica gel column, to give 169 mg of the title compound as colorless crystals (recrystallization solvent: ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07074801B1 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-5ebccfcfbcdc44148db4c42f0d9dc9ea |
| Source note | uspto-grants-2006_07 |