HCID 22031010, compound → HCID 178484453, compound

Participants

Reaction Steps

43 mg 6-{6-[3-(4-fluorophenyl)-1-trityl-1H-4-pyrazolyl]-1H-benzo[d]imidazol-1-yl}-N,N-dimethyl-nicotinamide (compound in Example 716) was dissolved in 8.0 mL solvent mixture of tetrahydrofuran and methanol (1:1), 3.0 mL of 5 N hydrochloric acid was added thereto, and the mixture was left at room temperature for 3 hours. The reaction solution was neutralized and then extracted with ethyl acetate. The extract was purified by silica gel column chromatography (ethyl acetate/methanol) and recrystallized from methanol/diethyl ether, to give 24 mg of the title compound as colorless crystals.

Provenance & Evidence