HCID 22032052, compound → HCID 22031082, compound

HRID 1792611Notes

Reaction equation

HRID 1792611 reaction equation
[CH3:1][S:2][C:3]1[S:7][C:6]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]4[C:19]([C:42]5[CH:51]=[CH:50][C:45]([C:46](OC)=[O:47])=[CH:44][CH:43]=5)=[N:20][N:21]([C:23]([C:36]5[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=5)([C:30]5[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=5)[C:24]5[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=5)[CH:22]=4)[CH:16]=3)[N:11]=[CH:10][N:9]=2)=[CH:5][CH:4]=1.CSC1SC(C2C3C(=CC=C(C4C(C5C=CC(C(OCC)=O)=CC=5)=NN(C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)C=4)C=3)N=CN=2)=CC=1>>[CH3:1][S:2][C:3]1[S:7][C:6]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]4[C:19]([C:42]5[CH:43]=[CH:44][C:45]([CH2:46][OH:47])=[CH:50][CH:51]=5)=[N:20][N:21]([C:23]([C:30]5[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=5)([C:24]5[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=5)[C:36]5[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=5)[CH:22]=4)[CH:16]=3)[N:11]=[CH:10][N:9]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 22032052HCID 22032052, compoundHCID 22032589HCID 22032589, compound

Product 1

HCID 22031082HCID 22031082, compound

Procedure

126 mg of the title compound was obtained as a yellow solid by the same method as in Example 359 from 238 mg mixture of methyl 4-{4-[4-(5-methylsulfanylthiophen-2-yl)quinazolin-6-yl]-1-trityl-1H-pyrazol-3-yl}benzoate and ethyl 4-{4-[4-(5-methylsulfanylthiophen-2-yl)quinazolin-6-yl]-1-trityl-1H-pyrazol-3-yl}benzoate obtained in the synthesis process in Example 771.

Sources & evidence

ORD record
ord-79b330565c1446cf9a71b8b3a34abecb
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

Loading…