Dimethylformamide → HCID 23537274, compound

Participants

Reaction Steps

A mixture of 100 mg 3-{4-[6-(1-trityl-1H-pyrazol-4-yl)quinazolin-4-yl]piperazin-1-yl} phenylamine obtained in Example 825, 30 mg pivaloyl chloride, 50 μl triethylamine and 10 mL N,N-dimethyl formamide was stirred at room temperature for 15 minutes. Water was added to the mixture which was then extracted with ethyl acetate, and the organic layer was washed with brine and dried over anhydrous magnesium sulfate. The solvent was evaporated, and the residue was purified by silica gel column chromatography to give 91 mg of the title compound as a colorless oil.

Provenance & Evidence