4-Methylbenzyl chloride → HCID 68813946, compound

Participants

Reaction Steps

100 mg 4-piperazin-1-yl-6-(1-trityl-1H-pyrazolyl) quinazoline (compound in Example 827) and 54 mg 1-chloromethyl-4-methyl benzene were dissolved in N,N-dimethylformamide, then 79 mg potassium carbonate was added thereto, and the mixture was stirred for about 5 hours at room temperature. The reaction solution was concentrated, and the residue was purified by silica gel column chromatography to give 150 mg of the title compound.

Provenance & Evidence