2-Chloroethyl methyl ether → HCID 86760169, compound

Participants

Reaction Steps

100 mg 5-{6-[3-(4-fluorophenyl)-1-trityl-1H-pyrazol-4-yl]quinazolin-4-yl}thiophen-2-sulfonic acid methylamide (compound in Example 745) and 15 μL 2-chloroethyl methyl ether were reacted in the same manner as in Example 746, to give 90 mg 5-{6-[3-(4-fluorophenyl)-1-trityl-1H-pyrazol-4-yl]quinazolin-4-yl}thiophen-2-sulfonic acid (2-methoxyethyl)-methylamide. This product was subjected to the same reaction as in Example 618, dissolved in dichloromethane/methanol and recrystallized from ethanol/ether, to give 35 mg of the title compound as orange crystals.

Provenance & Evidence