Morpholine, 4-(chloroacetyl)- → HCID 68812287, compound

Participants

Reaction Steps

100 mg 5-{6-[3-(4-fluorophenyl)-1-trityl-1H-pyrazol-4-yl]quinazolin-4-yl}thiophen-2-sulfonic acid methylamide (compound in Example 745) and 102 mg 4-(2-chloroacetyl)-morpholine were reacted in the same manner as in Example 746, to give 0.43 g 5-{6-[3-(4-fluorophenyl)-1-trityl-1H-pyrazol-4-yl]quinazolin-4-yl}thiophen-2-sulfonic acid methyl-(2-morpholin-4-yl-2-oxoethyl)amide. This product was subjected to the same reaction as in Example 618, dissolved in dichloromethane/methanol and recrystallized from ethanol/ether, to give 63 mg of the title compound as orange crystals.

Provenance & Evidence