HRID1792625

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CS(=O)(=O)c1ccccc1OC1CCN(c2ccnc3ccc(Br)cc23)CC1

HCID22031271

未命名化合物

结构：OB(O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)nc1C(F)(F)F

HCID22032227

未命名化合物

PRODUCTS

生成物

结构：CS(=O)(=O)c1ccccc1OC1CCN(c2ccnc3ccc(-c4cn(C(c5ccccc5)(c5ccccc5)c5ccccc5)nc4C(F)(F)F)cc23)CC1

HCID68815371

未命名化合物

收率 94.2%

PROCEDURE

实验过程

80 mg 6-bromo-4-[4-(2-methylsulfonylphenoxy)-piperidin-1-yl] quinoline (compound in Production Example 222) and 95 mg 3-trifluoromethyl-1-trityl-1H-4-pyrazolylboronic acid (compound in Production Example 31) were reacted in the same manner as in Example 9, to give 124 mg 4-[4-(2-methylsulfonylphenoxy)piperidin-1-yl]-6-(3-trifluoromethyl-1-trityl-1H-pyrazol-4-yl) quinoline. This product was reacted in the same manner as in Example 67, to give 70 mg of the title compound as colorless crystals.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ae4eadedae4b473b8faa9d7438f2e2d0
来源数据集: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07074801B1
来源说明: uspto-grants-2006_07

反应 SMILES

Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2[N:12]1[CH2:17][CH2:16][CH:15]([O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[S:25]([CH3:28])(=[O:27])=[O:26])[CH2:14][CH2:13]1.[F:29][C:30]([F:59])([F:58])[C:31]1[C:35](B(O)O)=[CH:34][N:33]([C:39]([C:52]2[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=2)([C:46]2[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=2)[C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[N:32]=1>>[CH3:28][S:25]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[O:18][CH:15]1[CH2:16][CH2:17][N:12]([C:5]2[C:4]3[C:9](=[CH:10][CH:11]=[C:2]([C:35]4[C:31]([C:30]([F:58])([F:59])[F:29])=[N:32][N:33]([C:39]([C:46]5[CH:47]=[CH:48][CH:49]=[CH:50][CH:51]=5)([C:52]5[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=5)[C:40]5[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=5)[CH:34]=4)[CH:3]=3)[N:8]=[CH:7][CH:6]=2)[CH2:13][CH2:14]1)(=[O:27])=[O:26]