6-Bromo-4-[4-(4-trifluoromethylsulfonylphenoxy)piperidin-1-yl] quinoline → 6-(1-trityl-1H-pyrazol-4-yl)-4-[4-(4-trifluoromethylsulfonylphenoxy)piperidin-1-yl] quinoline

Participants

Reaction Steps

150 mg 6-bromo-4-[4-(4-trifluoromethylsulfonylphenoxy)piperidin-1-yl] quinoline (compound in Production Example 456) and 134 mg 1-trityl-1H-4-pyrazolylboronic acid were reacted in the same manner as in Example 9, to give 205 mg 6-(1-trityl-1H-pyrazol-4-yl)-4-[4-(4-trifluoromethylsulfonylphenoxy)piperidin-1-yl] quinoline. This product was reacted in the same manner as in Example 67, to give 90 mg of the title compound as pale yellow crystals.

Provenance & Evidence