[3-(Trifluoromethyl)-1-trityl-1H-pyrazol-4-YL]boronic acid → 1-[6-(3-trifluoromethyl-1-trityl-1H-pyrazol-4-yl)quinolin-4-yl]-piperidine-4-carboxylic acid (4-fluorophenyl)methylamide

Participants

Reaction Steps

92 mg 1-(6-bromoquinolin-4-yl)piperidine-4-carboxylic acid (4-fluorophenyl)methylamide (compound in Production Example 458) and 114 mg 3-trifluoromethyl-1-trityl-1H-4-pyrazolylboronic acid (compound in Production Example 31) were reacted in the same manner as in Example 9, to give 139 mg 1-[6-(3-trifluoromethyl-1-trityl-1H-pyrazol-4-yl)quinolin-4-yl]-piperidine-4-carboxylic acid (4-fluorophenyl)methylamide. This product was reacted in the same manner as in Example 67, to give 80 mg of the title compound as pale yellow crystals.

Provenance & Evidence