2-Chlorobenzaldehyde → (2-Bromophenyl)[2-chloro-4-(E-((4-acetylhomopiperazin-1-yl)carbonyl) ethenyl)phenyl]sulfide

Participants

Reaction Steps

The title compound was prepared by the procedures described in Example 1 substituting 2,4-dichlorothiophenol with 2-bromothiophenol, 2-chlorobenzaldehyde with 3-chloro-4-fluoro-benzadehyde 3-chloro-3-fluoro-benzaldehyde, and 6-amino-1-hexanol with 4-acetylhomopiperazine. 1H NMR (DMSO-d6, 300 MHz) δ 8.10 (m, 1H), 7.81 (d, J=7.7 Hz, 1H), 7.64 (m, 1H), 7.24-7.51 (m, 5H), 7.05 (m, 1H), 3.39-3.77 (m, 8H), 1.97 (m, 3H), 1.68 (m, 2H). HRMS calculated for C22H22N2O2S1Br1Cl1: 493.0352. Observed: 493.0352.

Provenance & Evidence