Acetonitrile → HCID 178491439, compound

Participants

Reaction Steps

A stirred of mixture of 6-fluoro-3-(4-piperidinyl)-1H-indazole (1.9 g, 0.0086 mol), 1-[4-(4-bromobutoxy)-3-methoxyphenyl]ethanone 2.6 g, 0.0086 mol), K2CO3 (1.2 g), and acetonitrile (7.5 ml) was refluxed for 6 hr. The reaction was poured into water and a white solid settled from solution. This was collected, dried and afforded 3.2 g of product. The product was recrystallized from ethanol to yield 2.7 g (71%) of 1-[4-[4-[4-(6-fluoro-1H-indazol-3-yl)-1-piperidinyl]butoxy-3-methoxyphenyl]ethanone as glistening white flakes, m.p.=158°-160° C.

Provenance & Evidence