2-Methoxyethylamine → 2,4-dichloro-N-(2-methoxyethyl)benzenesulfonamide

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Reaction Steps

2,4-Dichlorobenzenesulphonyl chloride (500 mg 2.1 mmol) and 2-methoxyethylamine (230 mg, 3.1 mmol) in n-butanol (10 ml) was heated at reflux for one hour. The volatiles were removed by evaporation and residue purified by chromatography eluting with hexane/ethyl acetate (50:50) to give the title compound. NMR: 3.04 (t, 2H), 3.08 (s, 3H), 3.22 (t, 2H), 7.60 (dd, 1H), 7.82 (d, 1H), 7.92 (d, 1H), 8.0 (s, 1H); m/z: 282 [M−H]−.

Provenance & Evidence