2-Bromoethanol → HCID 22025148, compound

Participants

Reaction Steps

30 mg (0.09 mmol) of 2-amino-6-sulfanyl-4-[2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,5-pyridinedicarbonitrile [prepared analogously to Dyachenko et al., Russian Journal of Chemistry 33 (7), 1014–1017 (1997); 34 (4), 557–563 (1998)], 22 mg (0.18 mmol) of 2-hydroxyethyl bromide and 29 mg (0.35 mmol) of sodium bicarbonate are stirred in 1.5 ml of DMF at room temperature overnight. The reaction solution is purified directly by preparative HPLC on reversed-phase silica gel.

Provenance & Evidence