6-Chloro-1-benzothiophene-2-carboxylic acid → HCID 23540244, compound

HRID 1792779Notes

Reaction equation

HRID 1792779 reaction equation
[CH3:1][N:2]([CH3:21])[CH2:3][C@H:4]([C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]2[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]2)[CH2:10][CH2:9]1)=[O:7])[NH2:5].[Cl:22][C:23]1[CH:24]=[CH:25][C:26]2[CH:30]=[C:29]([C:31](O)=[O:32])[S:28][C:27]=2[CH:34]=1>>[ClH:22].[Cl:22][C:23]1[CH:24]=[CH:25][C:26]2[CH:30]=[C:29]([C:31]([NH:5][C@@H:4]([C:6]([N:8]3[CH2:9][CH2:10][CH:11]([CH:14]4[CH2:15][CH2:16][N:17]([CH3:20])[CH2:18][CH2:19]4)[CH2:12][CH2:13]3)=[O:7])[CH2:3][N:2]([CH3:21])[CH3:1])=[O:32])[S:28][C:27]=2[CH:34]=1

Participants

3

Reactant 2

HCID 71419196-Chloro-1-benzothiophene-2-carboxylic acidHCID 23540158HCID 23540158, compound

Product 1

HCID 23540244HCID 23540244, compound

Procedure

Prepared from 1-[β-dimethylamino-D-alaninyl]-4-(1-methylpiperidin-4-yl)piperidine and 6-chlorobenzo[b]thiophene-2-carboxylic acid using methods substantially equivalent to General Coupling Method 1. The HCl salt is prepared following General Salt Formation Method 1.

Sources & evidence

ORD record
ord-813543242f5f4c4dab084d52cfa4402d
Source dataset
uspto-grants-2006_07
Patent number
US07078415B2

Reaction notes

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