1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 131725863, compound

Participants

Reaction Steps

To 4-hydroxy-3,5-bis-nonyloxy benzoic acid (98 mg, 0.23 mmol), 1-(4-chlorophenyl)-2-piperazine-1-yl-ethanone (111 mg, 0.46 mmol), EDCI (89 mg, 0.46 mmol) and HOBT (63 mg, 0.46 mmol) was added MeCN (3 ml) and stirred for 1 hour at room temperature. The solution was added with NaHCO3 to finish the reaction. The solution was extracted with EtOAc, dried over anhydrous Na2SO4 and filtered. The obtained filterate was vacuum concentrated to give the residue, which was purified by column chromatography (Hexane:EtOAc=1:10), yielding 98 mg (66%) of 1-(4-chlorophenyl)-2-[4-(4-hydroxy-3,5-bis-pentyloxybenzoyl)piperizine -1-yl]ethanone.

Provenance & Evidence