HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 5-Chloro-alpha-(2-chlorophenyl)-2-(trifluoroacetylamino)benzyl alcohol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | (2-Amino-5-chlorophenyl)(2-chlorophenyl)methanol | HCID 11437092 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Chloro-alpha-(2-chlorophenyl)-2-(trifluoroacetylamino)benzyl alcohol | HCID 53991623 | 95.7% |
Reaction Steps
To a solution of 1.0 g of 2-amino-5-chloro-α-(2-chlorophenyl)benzyl alcohol in 12 ml of dichloromethane, a solution of 0.8 g of anhydrous trifluoroacetic acid in 2 ml of dichloromethane was added. After reaction, an aqueous solution of sodium hydrogen carbonate was added, and the organic layer was dried, after which the solvent was removed and the residue was recrystallized from hexane to yield 1.3 g of a crystal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05726306 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-39af1e12beb24e17a8267182051aa7af |
| Source note | uspto-grants-1998_03 |