Tetrahydrofuran → HCID 69597171, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-5-formyl-4-(3-chloro-4-methoxybenzylamino)pyrimidine (4.1 g) in tetrahydrofuran (30 ml) is added to a solution of vinyl magnesium bromide in tetrahydrofuran (43.5 ml) at 0° C., and the mixture is stirred at 0° C. for 1 hour. To the mixture is added a saturated aqueous ammonium chloride solution, and the mixture is extracted with ethyl acetate. The extract is washed with water and then brine, and dried over sodium sulfate. Sodium sulfate is removed by filtration, and the filtrate is concentrated in vacuo. The residue is purified by column chromatography (silica gel, 100 g; ethyl acetate→ethyl acetate:methanol=20:1, and then silica gel, 50 g; chloroform:methanol=50:1) to give (S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-5-(1-hydroxymethyl-2-propen-1-yl)-4-(3-chloro-4-methoxybenzylamino)pyrimidine (2.70 g) as colorless amorphous. MS(APCI): 405 (MH+).

Provenance & Evidence