HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Chlorophenacyl bromide → 6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Chlorophenacyl bromide | HCID 68303 | — |
| Reactant | 5-Benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole | HCID 9920580 | — |
| Product | 6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine | HCID 9945001 | — |
Reaction Steps
The 2-benzyl-4,4-dimethyl-1-pyrroline of the formula III is then cyclized with ω-bromo-4-chloroacetophenone to give the 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine of the formula II. The reaction is known from the prior art mentioned at the outset. ω-Bromo-4-chloroacetophenone can be obtained, for example, as described in Bull. Soc. Chim. Fr. 21, 69 (1899).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07078535B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-6ab0c792e2884cc19df6d6ecb4a193da |
| Source note | uspto-grants-2006_07 |