Potassium Phosphate, Tribasic → HCID 20318602, compound

Participants

Reaction Conditions

Reaction Steps

A Schlenk tube was charged with Pd(OAc)2 (16 mg, 0.07 mmol), K3PO4 (525 mg, 2.40 mmol), di-t-butylbiphenylphosphine (42 mg, 0.14 mmol) and the 7-hydroxyindole ester (see Example 6) (307 mg, 1.4 mmol), and capped with a septum and purged with argon. A solution of the benzyl ether from above (270 mg, 1.16 mmol) in 3 mL of toluene was then added via syringe. The mixture was heated at 100° C. with stirring under argon for 6 h. The reaction mixture was filtered through a layer of diatomaceous earth and the solid residue was rinsed with CH2Cl2. The combined filtrate was concentrated. The crude product was purified by column chromatography to give 61% yield of the desire indole ether.

Provenance & Evidence