HCID 10167748, compound → HCID 10229360, compound

HRID 1793256Notes

Reaction equation

HRID 1793256 reaction equation
[P:1]([O:13][CH2:14][C@@:15]1([CH2:30][NH:31]C(=O)C(F)(F)F)[O:19][C@@H:18]([N:20]2[CH:28]=[C:26]([CH3:27])[C:24](=[O:25])[NH:23][C:21]2=[O:22])[CH2:17][C@@H:16]1[OH:29])([O:4][P:5]([O:8][P:9]([OH:12])([OH:11])=[O:10])([OH:7])=[O:6])(=[O:3])[OH:2]>N>[P:1]([O:13][CH2:14][C@@:15]1([CH2:30][NH2:31])[O:19][C@@H:18]([N:20]2[CH:28]=[C:26]([CH3:27])[C:24](=[O:25])[NH:23][C:21]2=[O:22])[CH2:17][C@@H:16]1[OH:29])([O:4][P:5]([O:8][P:9]([OH:11])([OH:12])=[O:10])([OH:7])=[O:6])(=[O:2])[OH:3]

Participants

3

Reactant 1

HCID 10167748HCID 10167748, compound

Product 1

HCID 10229360HCID 10229360, compound

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

4′-C-(N-trifluoroacetylaminomethyl)thymidine triphosphate (8) was dissolved in concentrated aqueous ammonia solution and allowed to stand for 18 hours at ambient temperature. The solution was then lyophilised to give the title compound (9) as a white powder.

Sources & evidence

ORD record
ord-8cd46d3c7d05431fb2c0c7f3a7ae3da7
Source dataset
uspto-grants-2006_07
Patent number
US07078499B2

Reaction notes

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