反应详情

4′-C-(N-trifluoroacetylglycylaminomethyl)thymidine (5) (17 mg, 0.4 mmol) was dissolved in concentrated aqueous ammonia solution (1 mL) and allowed to stand overnight at ambient temperature. The reaction mixture was then lyophilised to give the title compound (22) as a colourless resin (0.0088 g, 67%). δH(300 MHz, D2O) 7.46(1H, s, H-6), 6.14(1H, dd, H-1′), 4.48(1H, dd, H-3′), 3.70(2H, s, glycyl CH2), 3.47(2H, 2d, H-5′), 3.40(2H, 2d, 4′-C—CH2), 2.35(2H, m, H-2′), 1.73(3H, s, 5-CH3); ES +ve m/z 329(M+H)+.