Potassium Nitrate → HCID 178526421, compound

Participants

Reaction Steps

Finely powdered potassium nitrate (1.01 g, 10 mmol) is added during 5 min. to a stirred solution of 6-chloro-2,3-dihydroxyquinoxaline (1.97 g, 10 mmol) in 50 ml of concentrated sulfuric acid at 0° C. After 1 h, the ice bath was removed and stirring continued for 2.5 h at room temperature. The mixture is poured into 200 ml of ice/water and the precipitate is isolated, washed with water, ethanol, and ether. The product is dissolved in 70 ml of hot 2N sodium hydroxide, filtered while hot, and reprecipitated with concentrated hypochloric acid to give 2.12 g (88%) of pure title compound. 3H-NMR (DMSO-d6): δ 7.23 (s, 1H, H-5); δ 7.82 (s, 1H, h-8); δ 12.1 (broad s, 2H, 2NH).

Provenance & Evidence