Acrylonitrile → HCID 22020968, compound

HRID 1793311Notes

Reaction equation

HRID 1793311 reaction equation
[CH3:1][C:2]([CH3:7])([CH2:5][NH2:6])[CH2:3][NH2:4].[C:8](#[N:11])[CH:9]=[CH2:10]>C(O)C>[NH2:4][CH2:3][C:2]([CH3:7])([CH3:1])[CH2:5][NH:6][CH2:10][CH2:9][C:8]#[N:11]

Participants

4

Reactant 2

HCID 7855Acrylonitrile2×HCID 817702,2-Dimethyl-1,3-propanediamine2×

Product 1

HCID 22020968HCID 22020968, compoundYield 79.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A mixture of 2,2 dimethyl-1,3-propanediamine (0.22 mol) and 2-propenenitrile (0.22 mol) in ethanol (250 ml) was stirred overnight at room temperature. The solvent was evaporated. A mixture of 2,2-dimethyl-1,3-propanediamine (0.28 mol) and 2-propenenitrile (0.28 mol) in ethanol (250 ml) was stirred for one hour at room temperature. The solvent was evaporated. The residues were combined. This fraction was purified by distillation, yielding 27.2 g of 3-[(3-amino-2,2-dimethylpropyl)amino]-propanenitrile (intermediate 11).

Workup

  1. customThe solvent was evaporated
  2. stirringwas stirred for one hour at room temperature
  3. customThe solvent was evaporated
  4. distillationThis fraction was purified by distillation

Sources & evidence

ORD record
ord-2579d2b9ed544c63b1824890ac07c44c
Source dataset
uspto-grants-2006_07
Patent number
US07081453B2

Reaction notes

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