2H-Pyrano[3,2-b]pyridine-3-methanol → 3,4-dihydro-2H-pyrano[3,2-b]pyridine-3-methanol

Participants

Role	Name	HCID	Charge
Reactant	2H-Pyrano[3,2-b]pyridine-3-methanol	HCID 22020943	—
Reactant	HCID 178418361	HCID 178418361	—
Catalyst	Palladium	HCID 23938	—
Solvent	Methanol	HCID 887	—
Product	3,4-dihydro-2H-pyrano[3,2-b]pyridine-3-methanol	HCID 22020965	78.5%

Reaction Steps

A mixture of intermediate (25) (0.0027 mol) in methanol (20 ml) was hydrogenated for 24 hours at room temperature with palladium-on-carbon (0.04 g) as a catalyst. After uptake of hydrogen (1 equivalent), the catalyst was filtered off and the filtrate was evaporated, yielding 0.35 g of 3,4-dihydro-2H-pyrano[3,2-b]pyridine-3-methanol (intermediate 26).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07081453B2
Source dataset	uspto-grants-2006_07
ORD ID	ord-b9cbd20a7d6a4baf8ad5eba19664bb6d
Source note	uspto-grants-2006_07