5-Amino-2-hydroxytoluene → 4-[(6,7-Dimethoxy-4-quinazolinyl)amino]-2-methylphenol

Participants

Reaction Steps

An analogous reaction to that described in example 17, but starting with 4-amino-2-methylphenol (6.98 g, 56.7 mmol) and 4-chloro-6,7-dimethoxyquinazoline hydrochloride (14.79 g, 56.7 mmol), yielded 4-(4-hydroxy-3-methylanilino)-6,7-dimethoxyquinazoline (17.72 g, 90% yield) as a white solid:

Provenance & Evidence