(4-Chloro-2-fluorophenyl)boronic acid → tert-butyl (6aS,10aR)-2-(4-chloro-2-fluorophenyl)-4,5,7,8,10,10a-hexahydropyrido[4,3-b]pyrrolo [3,2,1-hi]indole-9(6aH)-carboxylate

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Reaction Steps

The title compound was prepared by the method of Example 89 step C from tert-butyl(6aS,10aR)-2-bromo-4,5,7,8,10,10a-hexahydropyrido[4,3-b]pyrrolo[3,2,1-hi]indole-9(6aH)carboxylate (189 mg, 0.5 mmol) and corresponding 4-chloro-2-fluorophenyl boronic acid (175 mg, 1.0 mmol) to afford after chromatographic purification the title compound (128 mg, 60%). 1H NMR (CDCl3, 300 MHz) δ 7.28–7.29 (m,1H), 7.05–7.15 (m, 4H), 3.6–4.2 (m, 3H), 2.80–3.50 (m, 7H), 1.80–1.90 (m, 2H), 1.48 (s, 9H) ppm. MS-ApCI: 429 [M+H+].

Provenance & Evidence