(4-Methoxy-2-methylphenyl)boronic acid → HCID 10454824, compound

Participants

Reaction Steps

The title compound was prepared by the method of Example 89 step C from tert-butyl(6aS,10aR)-2-bromo-4,5,7,8,10,10a-hexahydropyrido[4,3-b]pyrrolo[3,2,1-hi]indole-9(6aH)carboxylate (189 mg, 0.5 mmol) and 4-methoxy-2-methylphenylboronic acid (166 mg, 1.0 mmol) to afford after chromatographic purification the title compound (105 mg, 50%). 1H NMR (CDCl3, 300 MHz) δ 7.04 (d, 1H, J=8.5 Hz), 6.65–6.79 (m, 4H), 3.75–4.22 (m, 2H), 3.74 (s, 3H), 3.58–3.68 (m, 1H), 3.18–3.42 (m, 4H), 2.76–3.16 (m, 3H), 2.17 (s, 3H), 1.70–1.84 (m, 2H), 1.40 (s, 9H) ppm. MS-ApCI: 421 [M+H+].

Provenance & Evidence