2,6-Dichlorobenzeneboronic acid → HCID 9997654, compound

Participants

Reaction Steps

The title compound was prepared by Example 305, Step A, from tert-butyl(6aS,10aR)-2-bromo-4,5,7,8,10,10a-hexahydropyrido[4,3-b]pyrrolo[3,2,1-hi]indole-9(6aH)-carboxylate and the corresponding 2,6-dichlorobenzeneboronic acid followed by hydrolysis of the resultant BOC protected amine adduct by the procedure of Example 305, Step B. 1H NMR (CDCl3, 300 MHz) δ 7.38 (dd, 2H), 7.15 (t, 1H), 6.80 (d, 1H), 6.73 (d, 1H), 3.69 (td, 1H), 3.57–3.30(m, 3H), 3.28–3.00 (m, 3H), 3.00–2.83 (m, 3H), 2.20 (bs, 2H), 2.00–1.81 (m, 2H). MS (CI): 346 (M+H+).

Provenance & Evidence