Ammonia → HCID 69437489, compound

Participants

Reaction Steps

The title compound was prepared by the method of Example 382 as a yellow oil (22 mg, 62%) from (7aS,11aR)-2-(2,3-dichlorophenyl)-5,6,7a,8,9,10,11,11a-octahydro-4H-pyrido[3′,4′:4,5]pyrrolo[3,2,1-ij]quinoline (30 mg, 0.083 mmol) and 5-bromo-1-pentene (25 mg, 0.17 mmol). 1H NMR (CDCl3, 300 MHz) δ 1.62–1.75 (br, 2H), 2.01–2.22 (m, 7H), 2.35–2.53 (br, 3H), 2.58–2.65 (m, 1H), 2.74 (t, J=6.6 Hz, 2H), 2.75–2.85 (br, 1H), 2.88–3.05 (br, 1H), 3.28–3.41 (m, 3H), 4.97 (d, J=13.5 Hz, 1H), 5.02 (dd, J=17.6, 1.5 Hz, 1H), 5.73–5.83 (m, 1H), 6.93 (s, 1H), 6.98 (s, 1H), 7.15–7.21 (m, 2H), 7.36–7.40 (m, 1H) ppm. MS (CI, NH3): 427.1 (base, M+H).

Provenance & Evidence