反应详情

温度

140 °C

1-phenylisatin (23.0 mg, 0.10 mmol) and 5-amino-2-chloropyridine (12.8 mg, 0.10 mmol) were mixed and heated at 140° C. for 7 h. The resulting crude product was purified by preparative TLC using hexane/ethyl acetate (8:2) as the eluent, giving the desired product as a yellow solid (19.7 mg, 59%). 1H NMR (400 MHz) δ 8.15 (d, J=8, 1H), 7.6–7.2 (m, 9H), 6.85–6.75 (m, 2H); ESI-MS m/z found 334 (MH+).

1. customThe resulting crude product was purified by preparative TLC