1-Phenylisatin → 3-[(2-Methyl-1,3-benzothiazol-5-YL)imino]-1-phenyl-1,3-dihydro-2H-indol-2-one

참여 물질

역할	이름	HCID	투입량
반응물	1-Phenylisatin	HCID 12884	—
반응물	5-Benzothiazolamine, 2-methyl-	HCID 36229	—
생성물	3-[(2-Methyl-1,3-benzothiazol-5-YL)imino]-1-phenyl-1,3-dihydro-2H-indol-2-one	HCID 9999162	32.3%

반응 조건

온도	140 °C

반응 단계

5-amino-2-methylbenzothiazole (52.2 mg, 0.31 mmol) was mixed with 1-phenylisatin (69.7 mg, 0.31 mmol) and heated at 140° C. for 3 h. The resulting crude product was purified by preparative TLC using ethyl acetate/hexane (6:4) as the eluent to give the desired product as a yellow solid (36.9 mg, 32.3%). 1H NMR Data: δ 7.9–6.7 (m, 12H), 2.9 (s, 3H). ESI-MS m/z found 370 (MH+).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07081470B2
출처 데이터셋	uspto-grants-2006_07
ORD ID	ord-207181d19e484bbaa07c19a722783cb4
출처 메모	uspto-grants-2006_07