Mesitylene → HCID 22022836, compound

HRID 1793630Notes

Reaction equation

C[O:2][C:3]([CH:5]1[CH2:10][CH2:9][CH:8]([NH2:11])[CH2:7][CH:6]1[OH:12])=O.C1(C)C=C(C)C=C(C)C=1>>[OH:12][CH:6]1[CH2:7][CH:8]2[CH2:9][CH2:10][CH:5]1[C:3](=[O:2])[NH:11]2

Participants

Reactant 2

HCID 7947Mesitylene

HCID 23542379HCID 23542379, compound

Product 1

HCID 22022836HCID 22022836, compound

Procedure

Reaction of compound (3) with mesitylene at elevated temperature (e.g., 165° C.) followed by cooling to rt yields 5-hydroxy-2-aza-bicyclo[2.2.2]octan-3-one (4).

Sources & evidence

ORD record: ord-b0e2dc13002843e39e1710ef993f97c6
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07081531B2

Reaction notes

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