HCID 69593390, compound → HCID 22022836, compound

HRID 1793636Notes

Reaction equation

HRID 1793636 reaction equation
C(O)(=O)C.C[O:6][C:7]([CH:9]1[CH2:14][CH2:13][CH:12]([NH2:15])[CH2:11][CH:10]1[OH:16])=O>C1(C)C=C(C)C=C(C)C=1>[OH:16][CH:10]1[CH2:11][CH:12]2[CH2:13][CH2:14][CH:9]1[C:7](=[O:6])[NH:15]2

Participants

3

Reactant 1

HCID 69593390HCID 69593390, compound

Product 1

HCID 22022836HCID 22022836, compoundYield 72.6%

Reagents, catalysts & solvents 1

HCID 7947MesityleneSolvent

Procedure

4-Amino-2-hydroxy-cyclohexanecarboxylic acid methyl ester acetic acid salt (6.6 g) was heated to reflux in mesitylene (60 ml) for 3 h. After cooling to rt, solvent was decanted and the crystals were washed with hexane three times to provide 2.9 g of 5-hydroxy-2-aza-bicyclo[2.2.2]octan-3-one (M+: 141).

Workup

  1. customsolvent was decanted
  2. washthe crystals were washed with hexane three times

Sources & evidence

ORD record
ord-ee14ef9802374bb18184286fb77e884c
Source dataset
uspto-grants-2006_07
Patent number
US07081531B2

Reaction notes

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