反应详情

A 1000 ml round-bottom flask is loaded with 67 g (0.319 mol) of 2-hydroxymethyl-3-methoxy-4-chloro-pyridine hydrochloride and 469 ml of toluene. 73 g (0.606 mol) of thionyl chloride are then dropped therein, under stirring and at inner temperature of about 15–25° C. After completion of the addition, the mixture is washed with 35 ml of toluene, keeping the suspension at this temperature for at least 1 hour. After completion of the reaction, approx. 200 ml of solvent are distilled off under vacuum. The suspension, containing 2-chloromethyl-3-methoxy-4-chloro-pyridine, is then subjected to the subsequent step.

1. additionAfter completion of the addition
2. washthe mixture is washed with 35 ml of toluene
3. customfor at least 1 hour
4. customAfter completion of the reaction, approx. 200 ml of solvent
5. distillationare distilled off under vacuum
6. additionThe suspension, containing 2-chloromethyl-3-methoxy-4-chloro-pyridine