1H-1,2,4-Triazole → HCID 22022973, compound

HRID 1793671Notes

Reaction equation

HRID 1793671 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[CH2:13][CH:12]([CH2:14][O:15][C:16]3[CH:20]=[CH:19][O:18][N:17]=3)[O:11][N:10]=2)[CH:5]=[CH:6][C:7]=1F.[NH:21]1[CH:25]=[N:24][CH:23]=[N:22]1>>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[CH2:13][CH:12]([CH2:14][O:15][C:16]3[CH:20]=[CH:19][O:18][N:17]=3)[O:11][N:10]=2)[CH:5]=[CH:6][C:7]=1[N:21]1[CH:25]=[N:24][CH:23]=[N:22]1

Participants

3

Reactant 2

HCID 92571H-1,2,4-TriazoleHCID 22022960HCID 22022960, compound

Product 1

HCID 22022973HCID 22022973, compound

Procedure

(5RS)-3-(3,4-Difluorophenyl)-5-isoxazol-3-yloxymethyl-4,5-dihydroisoxazole (140 mg, 0.5 mM) was treated with 1,2,4-triazole using essentially the conditions of Example 5. Crude product was chromatographed on a 5 g silica Mega Bond Elut® column, eluting with a gradient from 0–25% ethyl acetate in dichloromethane. Relevant fractions were combined to give the desired product (45 mg). MS (ESP): 330 (MH+) for C15H12FN5O3

Workup

  1. customCrude product was chromatographed on a 5 g silica Mega Bond Elut® column
  2. washeluting with a gradient from 0–25% ethyl acetate in dichloromethane

Sources & evidence

ORD record
ord-526c640f7c9b4043a4aca5333df303b6
Source dataset
uspto-grants-2006_07
Patent number
US07081538B1

Reaction notes

Loading…