Acetoxyacetyl chloride → HCID 22022958, compound

HRID 1793674Notes

Reaction equation

HRID 1793674 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:14]2[CH2:18][CH:17]([CH2:19][O:20][C:21]3[CH:25]=[CH:24][O:23][N:22]=3)[O:16][N:15]=2)[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.[C:26]([O:29][CH2:30][C:31](Cl)=[O:32])(=[O:28])[CH3:27]>>[F:1][C:2]1[CH:3]=[C:4]([C:14]2[CH2:18][CH:17]([CH2:19][O:20][C:21]3[CH:25]=[CH:24][O:23][N:22]=3)[O:16][N:15]=2)[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:13][CH2:12][N:11]([C:31](=[O:32])[CH2:30][O:29][C:26](=[O:28])[CH3:27])[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 26297Acetoxyacetyl chlorideHCID 22022977HCID 22022977, compound

Product 1

HCID 22022958HCID 22022958, compound

Procedure

(5RS)-3-(3-Fluoro-4-piperazin-1-ylphenyl)-5-isoxazol-3-yloxymethyl-4,5-dihydroisoxazole (175 mg, 0.51 mM) was treated with acetoxyacetyl chloride using essentially the conditions of Example 16, to give the desired product after chromatography and precipitation (163 mg).

Sources & evidence

ORD record
ord-d30f4d78e3b34e8cbf329c283d30a35d
Source dataset
uspto-grants-2006_07
Patent number
US07081538B1

Reaction notes

Loading…