HuagongsheHuagongshe Chemistry Print Report · For research reference only
Borane;tetrahydrofuran → HCID 69303662, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Borane;tetrahydrofuran | HCID 2723981 | — |
| Reactant | (3aS)-1-methyl-3,3-diphenyl-hexahydropyrrolo(1,2-c)(1,3,2)oxazaborole | HCID 2734713 | — |
| Reactant | 7-Chloro-5-(2-chloroacetyl)-1,3-dihydro-2H-indol-2-one | HCID 22021119 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 69303662 | HCID 69303662 | — |
Reaction Steps
To a solution of (S)-Methyl-CBS-oxazaborolidine (1M in toluene, 0.745 mL, 0.745 mmol) and BH3-THF (8 mL, 8 mmol) is added at the same time a solution of BH3-THF (19 mL, 19 mmol) and a solution of the 5-Chloroacetyl-7-chlorooxindole (37.98 mmol) in 19 mL of THF. Both solutions are added dropwise over 30 minutes. The solution is stirred for 1 hour and quenched with the slow addition of methanol (50 mL). The solution is concentrated and the residue chromatographed over a short silica gel column (1:1 hexane/ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07081454B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-388628bce0db46959552074fa18b9c22 |
| Source note | uspto-grants-2006_07 |