反应详情

温度

-78 °C

A 5-liter three-necked round bottom flask was equipped with an overhead mechanical stirrer under nitrogen, the flask was charged with THF (1 L) and cooled to −78° C. To this stirred solution was added tert-butyllithium (1.7 M solution in pentane) (800 mL, 1.36 mol) via canula followed by 2-methoxypyridine (132.2 g, 1.21 mol) at −78° C. The mixture was stirred for 1 h at −78° C. To the mixture was added N-formyl-N,N′,N′-trimethylethylenediamine (176 mL, 1.37 mol) dropwise at −78° C. The reaction mixture was stirred for ca. 30 min at −78° C. before warming to −23° C. over ca. 30 min. To the mixture at −23° C. was added ethylene glycol dimethyl ether (1 L) followed by n-butyllithium (2.5 M solution in hexane) (800 mL, 2.0 mol). The resulting mixture was stirred for ca. 2 h during which time the reaction mixture turned deep green. A 12-L 4-necked round flask was charged with iodine (571 g, 2.25 mol) and ethylene glycol dimethyl ether (2 L) and the resultant solution was cooled to −78° C. The contents of the 5-L flask were transferred via canula to the mixture of iodine and ethylene glycol dimethyl ether in the 12-L flask at −78° C. After the addition was complete, the reaction mixture was stirred for an additional 1 h at −78° C. The cooling bath was removed and the mixture was allowed to warm to about 0° C. and treated with 2 L of water and 2 L of 1 N hydrochloric acid. Methyl t-butyl ether (2L) was added and the layers were separated. The aqueous layer was extracted with 2×1 L of methyl t-butyl ether. The combined organic layers were washed with saturated Na2S2O3 (1.2 L), brine (1.2 L), dried over Na2SO4. After concentration in vacuo, the thick slurry was diluted with hexane (1 L). The mixture was cooled with an ice/water bath for ca. 30 min. The precipitate was filtered and dried in vacuum to yield the title compound as a light yellow solid. 1H NMR (300 MHz, CDCl3) δ 10.22 (s, 1H), 7.86 (1H, d, J=5.3 Hz), 7.54 (1H, d, J=5.3 Hz), 4.06 (3H, s). LCMS (M+H)+ m/z 364 (t=2.26 min.).

1. customA 5-liter three-necked round bottom flask was equipped with an overhead mechanical stirrer under nitrogen
2. stirringThe reaction mixture was stirred for ca. 30 min at −78° C.
3. temperaturebefore warming to −23° C. over ca. 30 min
4. stirringThe resulting mixture was stirred for ca. 2 h during which time the reaction mixture
5. additionAfter the addition
6. stirringthe reaction mixture was stirred for an additional 1 h at −78° C
7. customThe cooling bath was removed
8. temperatureto warm to about 0° C.
9. additiontreated with 2 L of water and 2 L of 1 N hydrochloric acid
10. additionMethyl t-butyl ether (2L) was added
11. customthe layers were separated
12. extractionThe aqueous layer was extracted with 2×1 L of methyl t-butyl ether
13. washThe combined organic layers were washed with saturated Na2S2O3 (1.2 L), brine (1.2 L)
14. dry with materialdried over Na2SO4
15. concentrationAfter concentration in vacuo
16. additionthe thick slurry was diluted with hexane (1 L)
17. temperatureThe mixture was cooled with an ice/water bath for ca. 30 min
18. filtrationThe precipitate was filtered
19. customdried in vacuum