2-[[6-(1H-Pyrazol-1-yl)-3-pyridinyl]methoxy]-1H-isoindole-1,3(2H)-dione → O-{[6-(1H-Pyrazol-1-yl)pyridin-3-yl]methyl}hydroxylamine

Participants

Reaction Steps

A solution of the compound of Step 7d (32 g, 0.1 mol) in 100 ml of 2M NH3 in methanol was stirred at 50° C. for 4 hours. The reaction mixture was subsequently concentrated in vacuo and purified on silica gel to give the desired compound of formula (XI) (18.5 g, 97%).

Provenance & Evidence