Hydrogen Peroxide → HCID 22220124, compound

Participants

Reaction Steps

The 5-Bromo-3-(4-fluoro-phenylsulfanyl)-1H-indole (1.34 g, 4.16 mmol) from Step 1 was suspended in formic acid (20 mL). To this was added 30% hydrogen peroxide (0.94 g, 8.3 mmole). The reaction mixture was stirred at room temperature for 1 hour. The mixture was diluted with 80 mL water and extracted with 100 mL ethyl acetate. The organic phase was washed with 1.5M sodium carbonate (20 mL, 30 mmol), dried (magnesium sulfate), and concentrated under reduced pressure. The residue was recrystallized from ether/hexane to provide 5-Bromo-3-(4-fluoro-benzenesulfonyl)-1H-indole (1.4 g, 4.0 mmol), m.p. 163–164°.

Provenance & Evidence