Chloroform → HCID 69596373, compound

Participants

Reaction Steps

To a solution of 1-(2-aminoethyl)piperidine (10.0 g, 78.0 mmol) and 2-fluoro-1-nitrobenzene (22.0 g, 156.0 mmol) in DMF (250 mL) was added diisopropylethylamine (12.5 mL) and the mixture was stirred at room temperature for 15 hours. The reaction mixture was poured into a mixture of CHCl3 and water. The water layer was extracted with CHCl3 and the combined organic layers were washed with water and brine, dried (Na2SO4), and evaporated, and the residue was purified by silica gel column chromatography to give 1 (17.6 g, 91%) as a yellowish solid.

Provenance & Evidence