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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1793892Generated: October 27, 2026

2,4-Dichlorobenzylidenemalononitrile → 5-(Aminomethyl)-6-(2,4-dichlorophenyl)-2-(4-fluorophenyl)pyrimidin-4-amine

https://huagongshe.com/reaction/1793892

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4-DichlorobenzylidenemalononitrileHCID 18089—
Reactant4-FluorobenzamidineHCID 4295238—
Product5-(Aminomethyl)-6-(2,4-dichlorophenyl)-2-(4-fluorophenyl)pyrimidin-4-amineHCID 10126186—

Reaction Steps

The title compound, MS: m/e=362.9 (M+H+), was prepared from 4-fluoro-benzamidine and 2-(2,4-dichloro-benzylidene)-malononitrile in analogy to the process described in Example 11 as a solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07022718B2
Source datasetuspto-grants-2006_04
ORD IDord-22d1b680a08d4c87a2ab0edd98f0fe40
Source noteuspto-grants-2006_04