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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1793902Generated: October 27, 2026

2,4-Dichlorobenzylidenemalononitrile → 5-Aminomethyl-6-(2,4-dichloro-phenyl)-2-thiophen-2-yl-pyrimidin-4-ylamine

https://huagongshe.com/reaction/1793902

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4-DichlorobenzylidenemalononitrileHCID 18089—
ReactantThiophene-2-carboximidamideHCID 2781760—
Product5-Aminomethyl-6-(2,4-dichloro-phenyl)-2-thiophen-2-yl-pyrimidin-4-ylamineHCID 22220608—

Reaction Steps

The title compound, MS: m/e=351.2 (M+H+), was prepared from thiophene-2-carboxamidine and 2-(2,4-dichloro-benzylidene)-malononitrile in analogy to the process described in Example 11 as a solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07022718B2
Source datasetuspto-grants-2006_04
ORD IDord-fd0d74999f964d7a91196f86f8894500
Source noteuspto-grants-2006_04