Water → HCID 86595212, compound

Participants

Reaction Steps

To a stirred solution of 0.15 g of tert-butyl [2-(2-amino-4-isopropylphenyl)ethyl]carbamate and 0.087 mL of pyridine in 2 mL of dichloromethane was added 0.072 mL of ethyl chlorooxoacetate under ice-cooling, and the mixture was stirred at room temperature for 4 hours. To the reaction mixture were added water and ethyl acetate, and the mixture was separated. The aqueous layer was extracted with ethyl acetate, and the organic layers were combined. After being washed with water and brine successively, the organic layer was dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to give 0.23 g of ethyl [2-(2-tert-butoxy-carbonylaminoethyl)-5-isopropylphenyl]oxalamate.

Provenance & Evidence